Various aspects of the present invention are directed to optical structures including selectively positioned color centers, methods of fabricating such optical structures, and photonic chips that utilize such optical structures. In one aspect of the present invention, an optical structure includes an optical medium having a number of strain-localization regions. A number of color centers are distributed within the optical medium in a generally selected pattern, with at least a portion of the strain-localization regions including one or more of the color centers. In another aspect of the present invention, a method of positioning color centers in an optical medium is disclosed. In the method, a number of strain-localization regions are generated in the optical medium. The optical medium is annealed to promote diffusion of at least a portion of the color centers to the strain-localization regions.