A loading-adjustable RF switch matrix circuit includes a first output unit for selectively outputting at least one RF signal, at least one signal switching module, and a detecting module coupled to the first output unit and the signal switching module. The signal switching module includes a first loading unit for adjusting the loading of the RF switch matrix circuit; a first switch unit coupled to the RF signal, the first loading unit and the first output unit for controlling the RF signal coupled to the first loading unit or the first output unit. If the detecting module detects that the first output unit is not coupled to a first external device, the first switch unit couples the RF signal to the first loading unit.