In a computer-readable medium, device and method for quantitative assessment of cardiac perfusion, a myocardium is depicted on a series of cardiac images and is divided into image segments. A cardiac perfusion parameter is determined for each of the image segments. At least one image segment with a normal perfusion parameter value is selected. The cardiac perfusion parameters of the remaining image segments are normalized based on the normal perfusion parameter value of said image segment with normal perfusion. The perfusion parameter can be a maximum upslope of a time-intensity profile for distribution of a contrast agent in said myocardium. A normal maximum upslope is derived for at least one image segment with normal perfusion and a relative maximum upslope is calculated for each other segment with relation to the normal maximum upslope.