In a system and a method for the guidance of a catheter with an electrode in an electrophysiological procedure, sequence of images of the catheter and of a resting reference catheter is generated with an X-ray device and stored together with the associated electrographic recordings from the electrodes. A reference image may then be selected from said sequence that corresponds to a desired electrographic pattern. In a next step, the positions of the catheters are localized on the reference image. The position of the reference catheter can be identified with the position of this catheter on an actual image. Thus it is possible to determine on the actual image also a target position for the catheter that corresponds to the position of this catheter on the reference image. The target position may finally be indicated on a monitor to assist the guidance of the catheter to a desired location.