The present disclosure provides a cable connector interface stabilization system, including: a component; one or more cables coupled to the component through one or more connectors; a spacer block disposed adjacent to the one or more connectors; and a retention member disposed adjacent to the one or more connectors opposite the spacer block and selectively secured to the spacer block, thereby securing the one or more connectors, and thereby securing the one or more cables to the component. The spacer block disposed adjacent to the one or more connectors is attached to one of a board and a heatsink assembly. The spacer block and the retention member surround the one or more connectors. The spacer block and the retention member secure the one or more connectors and secure the one or more cables to the component such that the associated connector-to-component interface(s) are fixed and immovable, ensuring that the associated electrical parameter(s) remain constant over time.