Invention Grant
US07807139B2 Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria
有权
使用外膜蛋白A（OMPA）治疗/预防/诊断由肺炎克雷伯杆菌和其他革兰氏阴性细菌引起的感染
- Patent Title: Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria
- Patent Title (中): 使用外膜蛋白A（OMPA）治疗/预防/诊断由肺炎克雷伯杆菌和其他革兰氏阴性细菌引起的感染
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Application No.: US12359205Application Date: 2009-01-23
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Publication No.: US07807139B2Publication Date: 2010-10-05
- Inventor: Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
- Applicant: Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
- Applicant Address: TW Taipei
- Assignee: Taipei Medical University
- Current Assignee: Taipei Medical University
- Current Assignee Address: TW Taipei
- Agency: WPAT, P.C.
- Agent Anthony King
- Main IPC: A61K49/00
- IPC: A61K49/00 ; A61K39/00 ; A61K39/108
Abstract:
The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
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