Invention Grant
US07807147B2 Tumor therapy with high affinity laminin receptor-targeted vectors
有权
肿瘤治疗与高亲和层粘连蛋白受体靶向载体
- Patent Title: Tumor therapy with high affinity laminin receptor-targeted vectors
- Patent Title (中): 肿瘤治疗与高亲和层粘连蛋白受体靶向载体
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Application No.: US11928564Application Date: 2007-10-30
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Publication No.: US07807147B2Publication Date: 2010-10-05
- Inventor: Daniel Meruelo
- Applicant: Daniel Meruelo
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: Fish & Richardson P.C.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/86
Abstract:
The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to alphavirus-based, preferably Sindbis virus-based, vectors and to non-alphavirus-based vectors, which have a preferential affinity for high affinity laminin receptors (HALR). These vectors are efficiently targeted to tumors and have the ability to cause tumor necrosis.
Public/Granted literature
- US20080125391A1 TUMOR THERAPY WITH HIGH AFFINITY LAMININ RECEPTOR-TARGETED VECTORS Public/Granted day:2008-05-29
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