Invention Grant
US07807148B2 Organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1a
有权
包括表达外源性HIF-1a的NIKS细胞的组织培养的皮肤组织
- Patent Title: Organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1a
- Patent Title (中): 包括表达外源性HIF-1a的NIKS细胞的组织培养的皮肤组织
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Application No.: US10848646Application Date: 2004-05-19
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Publication No.: US07807148B2Publication Date: 2010-10-05
- Inventor: Allen Comer , Lynn-Allen Hoffmann
- Applicant: Allen Comer , Lynn-Allen Hoffmann
- Applicant Address: US WI Madison
- Assignee: Stratatech Corporation
- Current Assignee: Stratatech Corporation
- Current Assignee Address: US WI Madison
- Agency: Casimir Jones SC
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N5/071
Abstract:
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Public/Granted literature
- US20050013807A1 Keratinocytes expressing exogenous angiogenic growth factors Public/Granted day:2005-01-20
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