Invention Grant
- Patent Title: Modified reoviral therapy
- Patent Title (中): 改良的呼肠孤病毒治疗
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Application No.: US11740985Application Date: 2007-04-27
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Publication No.: US07807179B2Publication Date: 2010-10-05
- Inventor: Jeffrey Tarrand , Xiang-Yang Han
- Applicant: Jeffrey Tarrand , Xiang-Yang Han
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Fulbright & Jaworski L.L.P.
- Main IPC: A61K35/00
- IPC: A61K35/00 ; C12N7/00
Abstract:
The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.
Public/Granted literature
- US20070280952A1 Modified Reoviral Therapy Public/Granted day:2007-12-06
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