Invention Grant
- Patent Title: Methods for predicting irinotecan toxicity
- Patent Title (中): 预测伊立替康毒性的方法
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Application No.: US10558510Application Date: 2004-05-28
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Publication No.: US07807350B2Publication Date: 2010-10-05
- Inventor: Mark J. Ratain , Federico Innocenti , Anna Di Rienzo , Carrie Grimsley
- Applicant: Mark J. Ratain , Federico Innocenti , Anna Di Rienzo , Carrie Grimsley
- Applicant Address: US IL Chicago
- Assignee: The University of Chicago
- Current Assignee: The University of Chicago
- Current Assignee Address: US IL Chicago
- Agency: Fulbright & Jaworski L.L.P.
- International Application: PCT/US2004/016920 WO 20040528
- International Announcement: WO2004/108954 WO 20041216
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C07H21/04 ; A61K31/44
Abstract:
The present invention concerns the methods and compositions for evaluating the risk of ironotecan toxicity in a cancer patient based on the genotype of the patient at position −3156 of the UGT1A1 gene or at any position in linkage disequilibrium with the −3156 variant.
Public/Granted literature
- US20070197574A1 Methods and compositions for predicting irinotecan toxicity Public/Granted day:2007-08-23
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