Invention Grant
US07807368B2 Cyclin-dependent kinase inhibitors as targets for opiod growth factor treatment
有权
细胞周期蛋白依赖性激酶抑制剂作为阿片类生长因子治疗的靶标
- Patent Title: Cyclin-dependent kinase inhibitors as targets for opiod growth factor treatment
- Patent Title (中): 细胞周期蛋白依赖性激酶抑制剂作为阿片类生长因子治疗的靶标
-
Application No.: US11901770Application Date: 2007-09-19
-
Publication No.: US07807368B2Publication Date: 2010-10-05
- Inventor: Ian S. Zagon , Patricia J. McLaughlin , Michael F. Verderame
- Applicant: Ian S. Zagon , Patricia J. McLaughlin , Michael F. Verderame
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention provides methods of cell cycle control by administering opioid growth factor (OGF), which activates opioid growth factor receptor (OGFr) signaling. Particularly, the present invention provides a method for monitoring OGF modulation or treatment of a cell proliferation or growth related condition in a subject by assessing the level of the cyclin dependent kinase inhibitor (CKI) relevant or corresponding to the condition. The present invention also provides a method for screening the eligibility of a subject for OGF modulation or treatment by assessing the level of OGF receptor (OGFr) and the relevant CKI. A method for enhancing the efficacy of OGF therapy by increasing the level of the relevant CKI and/or OGFr is also provided.
Public/Granted literature
- US20080146512A1 Cyclin-dependent kinase inhibitors as targets for opiod growth factor treatment Public/Granted day:2008-06-19
Information query
