Invention Grant
- Patent Title: Nitro-imidazole hypoxia imaging agents
- Patent Title (中): 硝基咪唑缺氧显像剂
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Application No.: US12098390Application Date: 2008-04-04
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Publication No.: US07807394B2Publication Date: 2010-10-05
- Inventor: Hartmuth C. Kolb , Joseph C. Walsh , Umesh B. Gangadharmath , Farhad Karimi , Henry Clifton Padgett , Dhanalakshmi Kasi , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Brian A. Duclos , Tieming Zhao
- Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Umesh B. Gangadharmath , Farhad Karimi , Henry Clifton Padgett , Dhanalakshmi Kasi , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Brian A. Duclos , Tieming Zhao
- Applicant Address: US PA Malvern
- Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee Address: US PA Malvern
- Agent Joshua B. Ryan
- Main IPC: C07D233/00
- IPC: C07D233/00 ; C07D249/00 ; G01N33/48 ; G01N33/574
Abstract:
The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
Public/Granted literature
- US20090010846A1 Nitro-Imidazole Hypoxia Imaging Agents Public/Granted day:2009-01-08
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