Invention Grant
- Patent Title: Detection of truncation mutations by mass spectrometry
- Patent Title (中): 通过质谱检测截短突变
-
Application No.: US10903612Application Date: 2004-07-30
-
Publication No.: US07807407B2Publication Date: 2010-10-05
- Inventor: Alex M. Garvin , Sadanand Gite , Vladislav B. Bergo , Kenneth J. Rothschild
- Applicant: Alex M. Garvin , Sadanand Gite , Vladislav B. Bergo , Kenneth J. Rothschild
- Applicant Address: US MA Watertown
- Assignee: AmberGen, Inc.
- Current Assignee: AmberGen, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Medlen & Carroll, LLP
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12P19/34 ; C12N9/50

Abstract:
This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference.
Public/Granted literature
- US20060024781A1 Detection of truncation mutations by mass spectrometry Public/Granted day:2006-02-02
Information query