Invention Grant
- Patent Title: Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
- Patent Title (中): 用于生产4-取代的3-羟基丁酸衍生物的酶法
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Application No.: US11502745Application Date: 2006-08-10
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Publication No.: US07807423B2Publication Date: 2010-10-05
- Inventor: S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
- Applicant: S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Dechert LLP
- Main IPC: C12P13/00
- IPC: C12P13/00 ; C12P7/62 ; C12N9/88
Abstract:
The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
Public/Granted literature
- US20070161094A1 Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives Public/Granted day:2007-07-12
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