Invention Grant
US07807444B2 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
有权
具有条件复制起点的圆形DNA分子，其制备方法及其在基因治疗中的应用
- Patent Title: Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
- Patent Title (中): 具有条件复制起点的圆形DNA分子，其制备方法及其在基因治疗中的应用
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Application No.: US11521412Application Date: 2006-09-15
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Publication No.: US07807444B2Publication Date: 2010-10-05
- Inventor: Fabienne Soubrier
- Applicant: Fabienne Soubrier
- Applicant Address: FR Vitry sur Seine
- Assignee: Centelion
- Current Assignee: Centelion
- Current Assignee Address: FR Vitry sur Seine
- Agency: Finnegan, Henderson Farabow, Garrett & Dunner LLP
- Priority: FR9510825 19950915
- Main IPC: C12N1/21
- IPC: C12N1/21 ; C12N15/70
Abstract:
A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described.
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