Invention Grant
- Patent Title: Factor V11 or factor V11A GLA domain variants
- Patent Title (中): 因子V11或因子V11A GLA结构域变体
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Application No.: US11424030Application Date: 2006-06-14
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Publication No.: US07807638B2Publication Date: 2010-10-05
- Inventor: Jesper Mortensen Haaning , Kim Vilbour Andersen , Claus Bornaes
- Applicant: Jesper Mortensen Haaning , Kim Vilbour Andersen , Claus Bornaes
- Applicant Address: US NY Tarrytown
- Assignee: Bayer Healthcare LLC
- Current Assignee: Bayer Healthcare LLC
- Current Assignee Address: US NY Tarrytown
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to human Factor VII or human Factor VIIa, wherein a hydrophobic amino acid residue has been introduced by substitution in position 34 or having an amino acid substitution in position 36 of the amino acid sequence shown in SEQ ID NO:1; and use of the variants for the treatment of intracerebral haemorrhage (ICH) or trauma.
Public/Granted literature
- US20060240526A1 FVII OR FVIIA GLA DOMAIN VARIANTS Public/Granted day:2006-10-26
Information query
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