Invention Grant
- Patent Title: G-rich polynucleotides for the treatment of Huntington's Disease
- Patent Title (中): 富G多核苷酸治疗亨廷顿氏病
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Application No.: US11544278Application Date: 2006-10-06
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Publication No.: US07807648B2Publication Date: 2010-10-05
- Inventor: Eric B. Kmiec , Hetal Parekh-Olmedo
- Applicant: Eric B. Kmiec , Hetal Parekh-Olmedo
- Applicant Address: US DE Newark
- Assignee: University of Delaware
- Current Assignee: University of Delaware
- Current Assignee Address: US DE Newark
- Agency: McCarter & English
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04
Abstract:
The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions. In particular, the invention relates to the use of a guanidine-rich oligonucleotides to disrupt disease-causing protein aggregates, for example, Huntington's Disease (HD) protein aggregates.
Public/Granted literature
- US20070105805A1 G-rich polynucleotides for the treatment of huntington's disease Public/Granted day:2007-05-10
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