Invention Grant
- Patent Title: Hyaluronic acid-methotrexate conjugate
- Patent Title (中): 透明质酸 - 甲氨蝶呤结合物
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Application No.: US11547158Application Date: 2005-04-01
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Publication No.: US07807675B2Publication Date: 2010-10-05
- Inventor: Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
- Applicant: Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
- Applicant Address: JP Tokyo
- Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
- Current Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Browdy and Neimark, PLLC
- Priority: JP2004-110423 20040402
- International Application: PCT/JP2005/006472 WO 20050401
- International Announcement: WO2005/095464 WO 20051013
- Main IPC: C07D475/00
- IPC: C07D475/00 ; A61K31/715
Abstract:
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
Public/Granted literature
- US20090093414A1 Hyaluronic Acid-Methotrexate Conjugate Public/Granted day:2009-04-09
Information query
IPC分类:
| C | 化学；冶金 |
| C07 | 有机化学 |
| C07D | 杂环化合物（高分子化合物入C08） |
| C07D475/00 | 含蝶啶环系的杂环化合物 |
