Invention Grant
US07807698B2 Azabicyclo[3.1.0]hexane derivatives as modulators of the dopamine D3 receptor
失效
氮杂双环[3.1.0]己烷衍生物作为多巴胺D3受体的调节剂
- Patent Title: Azabicyclo[3.1.0]hexane derivatives as modulators of the dopamine D3 receptor
- Patent Title (中): 氮杂双环[3.1.0]己烷衍生物作为多巴胺D3受体的调节剂
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Application No.: US11917355Application Date: 2006-06-13
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Publication No.: US07807698B2Publication Date: 2010-10-05
- Inventor: Luca Arista , Giorgio Bonanomi , Dieter Hamprecht , Fabrizio Micheli
- Applicant: Luca Arista , Giorgio Bonanomi , Dieter Hamprecht , Fabrizio Micheli
- Applicant Address: GB Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Middlesex
- Agent James M. Kanagy; Edward R. Gimmi; Charles M. Kinzig
- Priority: GB0512099.3 20050614; GB0604897.9 20060310
- International Application: PCT/EP2006/005767 WO 20060613
- International Announcement: WO2006/133945 WO 20061221
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D257/00 ; C07D249/08
![Azabicyclo[3.1.0]hexane derivatives as modulators of the dopamine D3 receptor](/abs-image/US/2010/10/05/US07807698B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl; p is an integer ranging from 0 to 5; R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5; or corresponds to a group R5; R2 is hydrogen or C1-4alkyl; R3 is C1-4alkyl; R4 is C1-4 alkyl or C1-6 cycloalkyl optionally substituted by 1 or 2 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; R5 is a moiety selected from the group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such a group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, as antipsychotic agents, or to treat obsessive compulsive spectrum disorders or premature ejaculation.
Public/Granted literature
- US20080227837A1 Novel Compounds Public/Granted day:2008-09-18
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