Invention Grant
- Patent Title: Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
- Patent Title (中): 11-和β-羟基类固醇脱氢酶1型抑制剂
-
Application No.: US11819607Application Date: 2007-06-28
-
Publication No.: US07807700B2Publication Date: 2010-10-05
- Inventor: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
- Applicant: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Foley & Lardner LLP
- Main IPC: A61K31/427
- IPC: A61K31/427 ; C07D277/14 ; C07D277/18
Abstract:
The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
Public/Granted literature
- US20080045503A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 Public/Granted day:2008-02-21
Information query
IPC分类:
