Invention Grant
US07807702B2 Substituted thiophene carboxylic amide glucagon receptor antagonists, preparation and therapeutic uses
有权
取代的噻吩羧酰胺胰高血糖素受体拮抗剂，制剂和治疗用途
- Patent Title: Substituted thiophene carboxylic amide glucagon receptor antagonists, preparation and therapeutic uses
- Patent Title (中): 取代的噻吩羧酰胺胰高血糖素受体拮抗剂，制剂和治疗用途
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Application No.: US12094406Application Date: 2006-11-21
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Publication No.: US07807702B2Publication Date: 2010-10-05
- Inventor: Mark Donald Chappell , Scott Eugene Conner , Philip-Arthur Hipskind , Allie Edward Tripp , Guoxin Zhu
- Applicant: Mark Donald Chappell , Scott Eugene Conner , Philip-Arthur Hipskind , Allie Edward Tripp , Guoxin Zhu
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Dan L. Wood
- International Application: PCT/US2006/061132 WO 20061121
- International Announcement: WO2007/120284 WO 20071025
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D257/04
Abstract:
The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
Public/Granted literature
- US20080300289A1 Glucagon Receptor Antagonists, Preparation and Therapeutic Uses Public/Granted day:2008-12-04
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