Invention Grant
US07807704B2 Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2
有权
调节CXCR4和/或CCXCKR2的双环含氮化合物
- Patent Title: Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2
- Patent Title (中): 调节CXCR4和/或CCXCKR2的双环含氮化合物
-
Application No.: US11731695Application Date: 2007-03-30
-
Publication No.: US07807704B2Publication Date: 2010-10-05
- Inventor: William D. Thomas , Manmohan Reddy Leleti , Andrew M. K. Pennell
- Applicant: William D. Thomas , Manmohan Reddy Leleti , Andrew M. K. Pennell
- Applicant Address: US CA Mountain View
- Assignee: Chemocentryx, Inc.
- Current Assignee: Chemocentryx, Inc.
- Current Assignee Address: US CA Mountain View
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: A01N43/38
- IPC: A01N43/38 ; A61K31/40 ; C09B5/00
Abstract:
The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These compounds are useful in preventing tumor cell proliferation, tumor formation, metastasis, inflammatory diseases, treatment of HIV infectivity, treatment of stem cell differentiation and mobilization disorders, and ocular disorders.
Public/Granted literature
- US20070275965A1 CXCR4 modulators Public/Granted day:2007-11-29
Information query
IPC分类:
