Invention Grant
US07807778B2 Cysteine-containing peptide tag for site-specific conjugation of proteins
有权
含有半胱氨酸的肽标签用于蛋白质的位点特异性缀合
- Patent Title: Cysteine-containing peptide tag for site-specific conjugation of proteins
- Patent Title (中): 含有半胱氨酸的肽标签用于蛋白质的位点特异性缀合
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Application No.: US12075811Application Date: 2008-03-14
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Publication No.: US07807778B2Publication Date: 2010-10-05
- Inventor: Marina V. Backer , Joseph M. Backer
- Applicant: Marina V. Backer , Joseph M. Backer
- Applicant Address: US CT Brookfield
- Assignee: SibTech, Inc.
- Current Assignee: SibTech, Inc.
- Current Assignee Address: US CT Brookfield
- Agency: Wiggin and Dana LLP
- Agent Todd E. Garabedian
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/18 ; C07K7/08 ; C07K14/475

Abstract:
The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety bound to the targeting moiety; the biological conjugate having a covalent bond between the thiol group of SEQ ID NO:2 and a functional group in the binding moiety. The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety that comprises an adapter protein, the adapter protein having a thiol group; the biological conjugate having a disulfide bond between the thiol group of SEQ ID NO:2 and the thiol group of the adapter protein. The present invention is also directed to biological sequences employed in the above biological conjugates, as well as pharmaceutical preparations and methods using the above biological conjugates.
Public/Granted literature
- US20080312410A1 Cysteine-containing peptide tag for site-specific conjugation of proteins Public/Granted day:2008-12-18
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