Invention Grant
- Patent Title: Reducing protein A leaching during protein A affinity chromatography
- Patent Title (中): 蛋白A亲和色谱法降低蛋白A浸出
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Application No.: US12269752Application Date: 2008-11-12
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Publication No.: US07807799B2Publication Date: 2010-10-05
- Inventor: Robert L. Fahrner , Amy Laverdiere , Paul J. McDonald , Rhona M. O'Leary
- Applicant: Robert L. Fahrner , Amy Laverdiere , Paul J. McDonald , Rhona M. O'Leary
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Arnold & Porter LLP
- Agent Diane Marschang; Ginger R. Dreger
- Main IPC: C07K16/00
- IPC: C07K16/00
Abstract:
A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
Public/Granted literature
- US20090099344A1 REDUCING PROTEIN A LEACHING DURING PROTEIN A AFFINITY CHROMATOGRAPHY Public/Granted day:2009-04-16
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