Invention Grant
US07807832B2 Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine
有权
通过2,4-二氯嘧啶的顺序官能化合成4 / 5-嘧啶基咪唑
- Patent Title: Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine
- Patent Title (中): 通过2,4-二氯嘧啶的顺序官能化合成4 / 5-嘧啶基咪唑
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Application No.: US11494060Application Date: 2006-07-27
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Publication No.: US07807832B2Publication Date: 2010-10-05
- Inventor: Xiaohu Deng , Neelakandha Mani
- Applicant: Xiaohu Deng , Neelakandha Mani
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Main IPC: C07D239/02
- IPC: C07D239/02
Abstract:
This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.
Public/Granted literature
- US20070027319A1 Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine Public/Granted day:2007-02-01
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