Invention Grant
US07807850B2 Preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-P-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
有权
制备2R，3S-N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基）-P-硝基苯磺酰胺盐酸盐和2-羟基-1,3-二胺的其它衍生物
- Patent Title: Preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-P-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
- Patent Title (中): 制备2R，3S-N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基）-P-硝基苯磺酰胺盐酸盐和2-羟基-1,3-二胺的其它衍生物
-
Application No.: US12190713Application Date: 2008-08-13
-
Publication No.: US07807850B2Publication Date: 2010-10-05
- Inventor: Aslam A. Malik , Hasan Palandoken , Joy A. Stringer , Roland P. Carlson , John Leach , Thomas G. Archibald , Robert G. Miotke
- Applicant: Aslam A. Malik , Hasan Palandoken , Joy A. Stringer , Roland P. Carlson , John Leach , Thomas G. Archibald , Robert G. Miotke
- Applicant Address: US CA Rancho Cordova
- Assignee: Ampac Fine Chemicals LLC
- Current Assignee: Ampac Fine Chemicals LLC
- Current Assignee Address: US CA Rancho Cordova
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: C07C303/36
- IPC: C07C303/36 ; C07C303/40 ; C07C303/00 ; C07C209/08 ; C07C271/20
Abstract:
The present invention provides a new process for the preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbuty1)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2R,3S-derivative, but also the 2S,3S-, 2S,2R- and the 2R,3R-derivatives.
Public/Granted literature
Information query
