Invention Grant
- Patent Title: Anti-addl antibodies and uses thereof
- Patent Title (中): 抗Addl抗体及其用途
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Application No.: US11577426Application Date: 2005-10-21
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Publication No.: US07811563B2Publication Date: 2010-10-12
- Inventor: Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
- Applicant: Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
- Applicant Address: US IL Evanston US NJ Rahway
- Assignee: Northwestern University,Merck & Co., Inc.
- Current Assignee: Northwestern University,Merck & Co., Inc.
- Current Assignee Address: US IL Evanston US NJ Rahway
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2005/038125 WO 20051021
- International Announcement: WO2006/055178 WO 20060526
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; G01N33/53
Abstract:
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Public/Granted literature
- US20080175835A1 Anti-Addl Antibodies and Uses Thereof Public/Granted day:2008-07-24
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