Invention Grant
US07811580B2 Chimeric HIV Env proteins comprising CD4 mini-proteins or CD4 mimetics that are capable of inducing neutralizing antibody responses against cryptic Env epitopes
有权
包含能够诱导针对隐性Env表位的中和抗体应答的CD4微型蛋白或CD4模拟物的嵌合HIV Env蛋白
- Patent Title: Chimeric HIV Env proteins comprising CD4 mini-proteins or CD4 mimetics that are capable of inducing neutralizing antibody responses against cryptic Env epitopes
- Patent Title (中): 包含能够诱导针对隐性Env表位的中和抗体应答的CD4微型蛋白或CD4模拟物的嵌合HIV Env蛋白
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Application No.: US10514055Application Date: 2003-05-07
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Publication No.: US07811580B2Publication Date: 2010-10-12
- Inventor: Susan Barnett , Indresh Srivastava
- Applicant: Susan Barnett , Indresh Srivastava
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines & Diagnostics, Inc.
- Current Assignee: Novartis Vaccines & Diagnostics, Inc.
- Current Assignee Address: US CA Emeryville
- Agent Regina Bautista; Helen Lee
- International Application: PCT/US03/14575 WO 20030507
- International Announcement: WO2004/037847 WO 20040506
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/21 ; C07H21/04 ; C12N5/00 ; C12N15/00
Abstract:
Env-CD4 complexes and hybrids are disclosed that expose cryptic epitopes that are important in virus neutralization. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
Public/Granted literature
- US20060073576A1 Hiv envelope-cd4 complexes and hybrids Public/Granted day:2006-04-06
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