Invention Grant
US07812148B2 Vectors comprising CpG islands without position effect varigation and having increased expression
有权
载体包含没有位置效应变异并具有增加的表达的CpG岛
- Patent Title: Vectors comprising CpG islands without position effect varigation and having increased expression
- Patent Title (中): 载体包含没有位置效应变异并具有增加的表达的CpG岛
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Application No.: US10117960Application Date: 2002-04-05
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Publication No.: US07812148B2Publication Date: 2010-10-12
- Inventor: Robert Lachlan Crombie , Steven Geraint Williams
- Applicant: Robert Lachlan Crombie , Steven Geraint Williams
- Applicant Address: US MA Billerica
- Assignee: Millipore Corporation
- Current Assignee: Millipore Corporation
- Current Assignee Address: US MA Billerica
- Agent Cozen O'Connor
- Priority: GB0109335.0 20010417
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A01N65/00 ; A01N43/04 ; A61K31/70
Abstract:
Polynucleotides and vectors comprising an expressible nucleic acid flanked by a 5′ extended methylation-free CpG island and a 3′ selectable marker element are disclosed. Such polynucleotides and vectors provide a means for obtaining high levels of expression of the flanked expressible nucleic acid. Preferred embodiments include combinations of 5′ extended methylation-free CpG islands and 3′ antibiotic resistance genes.
Public/Granted literature
- US20030166890A1 Gene expression Public/Granted day:2003-09-04
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