Invention Grant
- Patent Title: RNAi modulation of Aha and therapeutic uses thereof
- Patent Title (中): Aha的RNAi调节及其治疗用途
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Application No.: US11750553Application Date: 2007-05-18
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Publication No.: US07812150B2Publication Date: 2010-10-12
- Inventor: Rainer Constien , Birgit Bramlage , Pamela Tan , Hans-Peter Vornlocher , William Balch
- Applicant: Rainer Constien , Birgit Bramlage , Pamela Tan , Hans-Peter Vornlocher , William Balch
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: C07H21/04
- IPC: C07H21/04

Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an Aha gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier, methods for treating diseases caused by Aha1 expression and the expression of an Aha gene using the pharmaceutical composition; and methods for inhibiting the expression of an Aha gene in a cell.
Public/Granted literature
- US20080113931A1 RNAi MODULATION OF AHA AND THERAPEUTIC USES THEREOF Public/Granted day:2008-05-15
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