The invention is related to a control method to make IC's operation mode to be provided with uncertainty, wherein a Genetic Random Number is produced with the first use of IC, and a Run-Time Random Number is produced with every use of IC, both numbers are produced from the Random Number pool in IC, and then produce a long serial number through hash function, which include a plurality of control bits to serve as the function control of data shuffle for IC data access, path and direction for data flow, etc. The said long serial number varies with the random number during each time of execution, thus the control method of the long serial number is various and the IC's operation mode is provided with uncertainty. As IC is applied to e-commerce, data security or encryption/decryption process, due to the uncertainty of IC's behavior, a hacker cannot catch the fixed IC's operation mode to break through it just through analysis to a single IC, therefore the data security can be protected.