Invention Grant
- Patent Title: Implant for articular cartilage repair
- Patent Title (中): 植入物关节软骨修复
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Application No.: US11481955Application Date: 2006-07-07
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Publication No.: US07815926B2Publication Date: 2010-10-19
- Inventor: Carina Syring , Rudiger Walter Arthur von Versen
- Applicant: Carina Syring , Rudiger Walter Arthur von Versen
- Applicant Address: US NJ Edison
- Assignee: Musculoskeletal Transplant Foundation
- Current Assignee: Musculoskeletal Transplant Foundation
- Current Assignee Address: US NJ Edison
- Agency: Greenberg Traurig, LLP
- Main IPC: A61F2/00
- IPC: A61F2/00 ; C12N5/07 ; C12N11/14 ; C12N11/10

Abstract:
An implant for articular cartilage repair includes (1) a three-dimensional body formed of cancellous bone having a demineralized section that contains bone morphogenetic proteins (BMP's) that are released by the demineralization but retained in the body, and (2) a cartilage layer formed on a surface of the demineralized section. The cartilage layer is formed by a method including the steps of (a) isolating chondrocytes from articular cartilage of a donor; (b) cultivating the isolated chondrocytes in a medium; (c) suspending the cultivated chondrocytes in agarose; (d) adding the cultivated chondrocytes to the demineralized section of the body, whereby the cultivated chondrocytes are stimulated by the BMP's retained in the body; and (e) incubating the cultivated chondrocytes to form a plurality of layers of chondrocytes on the demineralized section, wherein the plurality of layers of chondrocytes forms the cartilage layer.
Public/Granted literature
- US20070009610A1 Engineered osteochondral construct for treatment of articular cartilage defects Public/Granted day:2007-01-11
Information query
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