Invention Grant
- Patent Title: Quick dissolve compositions and tablets based thereon
- Patent Title (中): 快速溶解组合物和片剂
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Application No.: US10176135Application Date: 2002-06-21
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Publication No.: US07815937B2Publication Date: 2010-10-19
- Inventor: Naima Mezaache , Steven E. Frisbee , Patrick B. Woodall , Mark R. Herman , Djelila Mezaache
- Applicant: Naima Mezaache , Steven E. Frisbee , Patrick B. Woodall , Mark R. Herman , Djelila Mezaache
- Applicant Address: BB St. Michael
- Assignee: Biovail Laboratories International SRL
- Current Assignee: Biovail Laboratories International SRL
- Current Assignee Address: BB St. Michael
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P
- Main IPC: A61K9/20
- IPC: A61K9/20

Abstract:
The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.
Public/Granted literature
- US20030124184A1 Quick disolve compositions and tablets based thereon Public/Granted day:2003-07-03
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