Invention Grant
US07816073B2 Method for inhibiting bacterial growth in a leuko-reduced platelet concentrate by adding L-carnitine
失效
通过加入左旋肉碱来抑制白细胞减少的血小板浓缩物中的细菌生长的方法
- Patent Title: Method for inhibiting bacterial growth in a leuko-reduced platelet concentrate by adding L-carnitine
- Patent Title (中): 通过加入左旋肉碱来抑制白细胞减少的血小板浓缩物中的细菌生长的方法
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Application No.: US10756368Application Date: 2004-01-14
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Publication No.: US07816073B2Publication Date: 2010-10-19
- Inventor: Secondo Dottori , Arduino Arduini
- Applicant: Secondo Dottori , Arduino Arduini
- Applicant Address: IT Rome
- Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- Current Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- Current Assignee Address: IT Rome
- Agency: Lucas & Mercanti, LLP
- Main IPC: A01N1/02
- IPC: A01N1/02
Abstract:
Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.
Public/Granted literature
- US20040146846A1 Storage and maintenance of blood products including red blood cells and platelets Public/Granted day:2004-07-29
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