Invention Grant
US07816349B2 Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
失效
取代的吡咯烷酮作为11-β-羟基类固醇脱氢酶1的抑制剂
- Patent Title: Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 取代的吡咯烷酮作为11-β-羟基类固醇脱氢酶1的抑制剂
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Application No.: US12297969Application Date: 2007-04-23
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Publication No.: US07816349B2Publication Date: 2010-10-19
- Inventor: John Gordon Allen , Alexei Pavlovych Krasutsky , Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- Applicant: John Gordon Allen , Alexei Pavlovych Krasutsky , Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Dan L. Wood
- International Application: PCT/US2007/067200 WO 20070423
- International Announcement: WO2007/127693 WO 20071108
- Main IPC: A61K31/54
- IPC: A61K31/54 ; A61K31/535 ; A61K31/445 ; A61K31/497 ; C07D401/10 ; C07D403/10 ; C07D413/10 ; C07D417/10
Abstract:
The present invention discloses novel compounds of Formula I: (I) possessing 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11β-HSD type 1 activity.
Public/Granted literature
- US20090069326A1 SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 Public/Granted day:2009-03-12
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