Invention Grant
- Patent Title: MTP inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles
- Patent Title (中): MTP抑制芳基哌啶或被5元杂环取代的哌嗪
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Application No.: US12341567Application Date: 2008-12-22
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Publication No.: US07816360B2Publication Date: 2010-10-19
- Inventor: Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
- Applicant: Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP04075771 20040310
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/454 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D417/12 ; C07D487/04 ; C07D233/74 ; C07D249/12
Abstract:
The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
Public/Granted literature
- US20100004263A1 MTP INHIBITING ARYL PIPERIDINES OR PEPERAZINES SUBSTITUTED WITH5-MEMBERED HETEROCYCLES Public/Granted day:2010-01-07
Information query
IPC分类:
