Invention Grant
US07816400B2 Use of acacetin and related compounds as potassium channel inhibitors
有权
使用醋酸丙锭和相关化合物作为钾通道抑制剂
- Patent Title: Use of acacetin and related compounds as potassium channel inhibitors
- Patent Title (中): 使用醋酸丙锭和相关化合物作为钾通道抑制剂
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Application No.: US12039921Application Date: 2008-02-29
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Publication No.: US07816400B2Publication Date: 2010-10-19
- Inventor: Gui-Rong Li , Chu-Pak Lau , Guo-Wei Qin , Hong-Bing Wang
- Applicant: Gui-Rong Li , Chu-Pak Lau , Guo-Wei Qin , Hong-Bing Wang
- Applicant Address: CN Hong Kong CN Shanghai
- Assignee: The University of Hong Kong,Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Current Assignee: The University of Hong Kong,Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Current Assignee Address: CN Hong Kong CN Shanghai
- Agency: Saliwanchik, Lloyd & Saliwanchik
- Main IPC: A61K31/352
- IPC: A61K31/352 ; A61P9/06
Abstract:
This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).
Public/Granted literature
- US20080214493A1 Use of Flavone Compounds as Potassium Channel Inhibitors Public/Granted day:2008-09-04
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