Invention Grant
US07816490B2 Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases
有权
钙调神经磷酸酶NFAT激活的特异性抑制剂及其在治疗免疫相关疾病中的应用
- Patent Title: Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases
- Patent Title (中): 钙调神经磷酸酶NFAT激活的特异性抑制剂及其在治疗免疫相关疾病中的应用
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Application No.: US12260049Application Date: 2008-10-28
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Publication No.: US07816490B2Publication Date: 2010-10-19
- Inventor: Patrick G. Hogan , Anjana Rao , Jose Aramburu
- Applicant: Patrick G. Hogan , Anjana Rao , Jose Aramburu
- Applicant Address: US MA Boston
- Assignee: Immune Disease Institute, Inc.
- Current Assignee: Immune Disease Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: C07K7/00
- IPC: C07K7/00 ; C07K7/06 ; C07K7/08 ; C07K14/00
Abstract:
Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.
Public/Granted literature
- US20090186422A1 SPECIFIC INHIBITORS OF NFAT ACTIVATION BY CALCINEURIN AND THEIR USE IN TREATING IMMUNE-RELATED DISEASES Public/Granted day:2009-07-23
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