Invention Grant
US07816497B2 Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration
有权
用于抑制玻璃疣补体成分C3a和C5a用于治疗年龄相关性黄斑变性的组合物和方法
- Patent Title: Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration
- Patent Title (中): 用于抑制玻璃疣补体成分C3a和C5a用于治疗年龄相关性黄斑变性的组合物和方法
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Application No.: US11199374Application Date: 2005-08-09
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Publication No.: US07816497B2Publication Date: 2010-10-19
- Inventor: Jayakrishna Ambati
- Applicant: Jayakrishna Ambati
- Applicant Address: US KY Lexington
- Assignee: University of Kentucky
- Current Assignee: University of Kentucky
- Current Assignee Address: US KY Lexington
- Agency: McDermott Will & Emery LLP
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08
Abstract:
Activated C3 (C3a) and its receptor (C3aR) and activated C5 (C5a) and its receptor (C5aR) have been shown to induce vascular endothelial growth factor (VEGF) expression in vitro and in vivo. Compositions and methods for inhibiting C3a, C3aR, C5a and C5aR for the treatment and/or prevention of neovascular disease are provided. Also provided are Novel therapeutic targets and diagnostic markers for choroidal neovascularization.
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