A latch-up protection circuit for LCD driver is provided. The latch-up protection circuit for LCD driver comprises an NMOS, a switch and a capacitor. The NMOS comprises a drain electrically connected to a ground; a source electrically connected to a negative voltage source; and a gate. The switch is electrically connected to the gate to receive a control signal, wherein the switch switches between a positive voltage source and the negative voltage source according to the control signal; and the capacitor is electrically connected to the positive voltage source and the gate.