A method and system for predisposition modification are presented in which a set of attributes for selective modification of the attribute profile of an individual are determined to enable the individual to modify their predisposition for acquiring an attribute of interest. The attribute of interest can be input in the form of a query attribute along with a minimum strength of association value which serves as a threshold to ensure that the results will provide at least a minimum degree of statistical certainty that the individual will acquire the attribute of interest upon modifying their attribute profile.