Invention Grant
- Patent Title: Circulating mRNA as diagnostic markers
- Patent Title (中): 循环mRNA作为诊断标记
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Application No.: US11807258Application Date: 2007-05-24
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Publication No.: US07829285B2Publication Date: 2010-11-09
- Inventor: Yuk-Ming Dennis Lo , Kai On Ng , Bo Yin Tsui , Wai Kwun Rossa Chiu
- Applicant: Yuk-Ming Dennis Lo , Kai On Ng , Bo Yin Tsui , Wai Kwun Rossa Chiu
- Applicant Address: HK Shatin, New Territories, SAR
- Assignee: The Chinese University of Hong Kong
- Current Assignee: The Chinese University of Hong Kong
- Current Assignee Address: HK Shatin, New Territories, SAR
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C07H21/02 ; C07H21/04
Abstract:
Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclampsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more mRNA species encoding human chorionic gonadotropin β subunit (hCG-β), human placental lactogen (hPL), human corticotropin releasing hormone (hCRH), KiSS-1 metastasis-suppressor (KISS1), tissue factor pathway inhibitor 2 (TPFI2), placenta-specific 1 (PLAC1), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and comparing the amount of the mRNA species with a standard control.
Public/Granted literature
- US20090162842A1 Circulating mRNA as diagnostic markers Public/Granted day:2009-06-25
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