Invention Grant
- Patent Title: Adenoviral vectors for treating disease
- Patent Title (中): 用于治疗疾病的腺病毒载体
-
Application No.: US10306275Application Date: 2002-11-27
-
Publication No.: US07829329B2Publication Date: 2010-11-09
- Inventor: Terry Hermiston , Lynda K. Hawkins , Leisa Johnson
- Applicant: Terry Hermiston , Lynda K. Hawkins , Leisa Johnson
- Applicant Address: US CA Emeryville
- Assignee: Onyx Pharmaceuticals, Inc.
- Current Assignee: Onyx Pharmaceuticals, Inc.
- Current Assignee Address: US CA Emeryville
- Agent Gary R. Fabian; Gregory J. Giotta
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N7/00 ; A01N43/04

Abstract:
Adenoviral vectors, including mutant adenoviruses, that have restriction sites in the E3 region, that facilitate its partial or total deletion, or select genes contained therein, and optionally compositions and methods for substituting heterologous gene(s) in the partially or totally deleted E3 region(s), which heterologous gene(s) being operably linked to endogenous adenoviral transcriptional control sequences will exhibit an expression pattern, both in terms of timing and degree of expression, similar to the endogenous adenoviral gene(s) that it replaces, and further optionally including mutations in other parts of the adenoviral genome, including certain E1B or E1A regions, and that have applications for diagnosing or treating disease, preferably disease involving unwanted cell growth, including cancer.
Public/Granted literature
- US20040101512A1 Adenoviral vectors for treating disease Public/Granted day:2004-05-27
Information query
IPC分类: