Invention Grant
US07829332B2 Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom
有权
嘌呤是神经干细胞的自我更新信号，嘌呤受体拮抗剂促进神经元和胶质细胞分化
- Patent Title: Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom
- Patent Title (中): 嘌呤是神经干细胞的自我更新信号，嘌呤受体拮抗剂促进神经元和胶质细胞分化
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Application No.: US11054919Application Date: 2005-02-10
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Publication No.: US07829332B2Publication Date: 2010-11-09
- Inventor: Steven A. Goldman , Maiken Nedergaard , Jane Lin
- Applicant: Steven A. Goldman , Maiken Nedergaard , Jane Lin
- Applicant Address: US NY Ithaca US NY Valhalla
- Assignee: Cornell Research Foundation, Inc.,New York Medical College
- Current Assignee: Cornell Research Foundation, Inc.,New York Medical College
- Current Assignee Address: US NY Ithaca US NY Valhalla
- Agency: Nixon Peabody LLP
- Main IPC: C12N5/06
- IPC: C12N5/06
Abstract:
The present invention relates to a method of inhibiting differentiation of a population of neural stem cells by contacting a purinergic receptor agonist and a population of neural stem cells under conditions effective to inhibit differentiation of the population of neural stem cells. Another aspect of the present invention relates to a method of producing neurons and/or glial cells from a population of neural stem cells by culturing a population of neural stem cells with a purinergic receptor antagonist under conditions effective to cause the neural stem cells to differentiate into neurons and/or glial cells. The purinergic receptor agonist can also be used in a method of inducing proliferation and self-renewal of neural stem cells in a subject and a method of treating a neurological disease or neurodegenerative condition in a subject. The purinergic receptor antagonist can also be used in treating a neoplastic disease of the brain or spinal cord in a subject.
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