Invention Grant
- Patent Title: Modulation of hedgehog-mediated signaling pathway
- Patent Title (中): 调节hedgehog介导的信号通路
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Application No.: US11438933Application Date: 2006-05-22
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Publication No.: US07829333B2Publication Date: 2010-11-09
- Inventor: Philip A. Beachy , Ming-Jer Tsai , Sophia Tsai , Venkatesh Krishnan , Chien-Huan Chen
- Applicant: Philip A. Beachy , Ming-Jer Tsai , Sophia Tsai , Venkatesh Krishnan , Chien-Huan Chen
- Applicant Address: US MD Baltimore US TX Houston
- Assignee: The Johns Hopkins University School of Medicine,Baylor College of Medicine
- Current Assignee: The Johns Hopkins University School of Medicine,Baylor College of Medicine
- Current Assignee Address: US MD Baltimore US TX Houston
- Agency: DLA Piper LLP (US)
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12Q1/68
Abstract:
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
Public/Granted literature
- US20060211114A1 Modulation of hedgehog-mediated signaling pathway Public/Granted day:2006-09-21
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