Invention Grant
US07829503B2 Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-fungal agents
有权
鉴定靶向tRNA剪接核酸内切酶的化合物的方法和所述化合物用作抗真菌剂的方法
- Patent Title: Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-fungal agents
- Patent Title (中): 鉴定靶向tRNA剪接核酸内切酶的化合物的方法和所述化合物用作抗真菌剂的方法
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Application No.: US10551304Application Date: 2004-03-26
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Publication No.: US07829503B2Publication Date: 2010-11-09
- Inventor: Christopher R. Trotta
- Applicant: Christopher R. Trotta
- Applicant Address: US NJ South Plainfield
- Assignee: PTC Therapeutics, Inc.
- Current Assignee: PTC Therapeutics, Inc.
- Current Assignee Address: US NJ South Plainfield
- Agency: Jones Day
- International Application: PCT/US2004/009574 WO 20040326
- International Announcement: WO2004/087070 WO 20041014
- Main IPC: C40B30/06
- IPC: C40B30/06 ; C40B40/08 ; A61K31/00
Abstract:
The present invention relates to a method for screening and identifying compounds that modulate the activity of a fungal tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit or reduce the activity of a fungal tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for preventing, treating, managing and/or ameliorating a fungal infection or fungal infestation or one or more symptoms thereof.
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