Invention Grant
US07829528B2 Compositions and methods for treating STAT-6 associated diseases or conditions
有权
用于治疗STAT-6相关疾病或病症的组合物和方法
- Patent Title: Compositions and methods for treating STAT-6 associated diseases or conditions
- Patent Title (中): 用于治疗STAT-6相关疾病或病症的组合物和方法
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Application No.: US11575164Application Date: 2005-09-12
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Publication No.: US07829528B2Publication Date: 2010-11-09
- Inventor: Elizabeth D. Fixman , Christine T. McCusker
- Applicant: Elizabeth D. Fixman , Christine T. McCusker
- Applicant Address: US NY New York
- Assignee: The Rockefeller University
- Current Assignee: The Rockefeller University
- Current Assignee Address: US NY New York
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2005/032948 WO 20050912
- International Announcement: WO2006/031976 WO 20060323
- Main IPC: C07K14/00
- IPC: C07K14/00
Abstract:
The present invention relates to a cell permeable peptide to specifically inhibit tyrosine phosphorylation and/or subsequent activation of STAT-6. This peptide is composed of a protein transduction moiety operably linked to a portion of STAT-6 which contains tyrosine residue 641 (Tyr-641) of STAT-6, wherein Tyr-641 is phosphorylated. The chimeric STAT-6 peptide enters cells and binds to the SH2 domain of wild-type STAT-6, and subsequently inhibits dimerization and nuclear translocation of the wild-type STAT-6 protein. Administration of this chimeric peptide inhibits allergen-induced airway inflammation, cytokine production and airway hyperresponsiveness and is useful in methods for preventing or treating diseases or conditions associated with STAT-6 activation.
Public/Granted literature
- US20080113909A1 Compositions and Methods for Treating Stat-6 Associated Diseases or Conditions Public/Granted day:2008-05-15
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