Invention Grant
- Patent Title: Aminoamides as orexin antagonists
- Patent Title (中): 氨基酰胺作为食欲肽拮抗剂
-
Application No.: US12037975Application Date: 2008-02-27
-
Publication No.: US07829563B2Publication Date: 2010-11-09
- Inventor: Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- Applicant: Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP07103521 20070305
- Main IPC: A61K31/50
- IPC: A61K31/50 ; A61K31/501 ; A61K31/497 ; A01N43/54 ; C07D239/42 ; C07D401/04 ; A01N43/40 ; A61K31/435 ; A01N43/78 ; A61K31/425 ; A01N43/50 ; A61K31/415 ; A01N43/56 ; A01N43/08 ; A61K31/34 ; C07D279/00 ; C07D285/00 ; C07D401/00 ; C07D421/00 ; C07D419/00 ; C07D277/04 ; C07D277/08 ; C07D409/00 ; C07D335/00 ; C07D333/02 ; C07D321/00 ; C07D307/00 ; C07D317/00 ; C07D323/02

Abstract:
The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
Public/Granted literature
- US20080221166A1 AMINOAMIDES AS OREXIN ANTAGONISTS Public/Granted day:2008-09-11
Information query