Invention Grant
US07829582B2 Piperidinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
失效
哌啶基取代的吡咯烷酮作为11-β-羟基类固醇脱氢酶1的抑制剂
- Patent Title: Piperidinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 哌啶基取代的吡咯烷酮作为11-β-羟基类固醇脱氢酶1的抑制剂
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Application No.: US12297951Application Date: 2007-04-27
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Publication No.: US07829582B2Publication Date: 2010-11-09
- Inventor: Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- Applicant: Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Dan L. Wood
- International Application: PCT/US2007/067597 WO 20070427
- International Announcement: WO2007/127901 WO 20071108
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D211/56 ; C07D211/92
Abstract:
The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.
Public/Granted literature
- US20090088430A1 PIERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 Public/Granted day:2009-04-02
Information query
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