Invention Grant
US07829668B2 Compositions and methods for modifying toxic effects of proteinaceous compounds
有权
用于改变蛋白质化合物毒性作用的组合物和方法
- Patent Title: Compositions and methods for modifying toxic effects of proteinaceous compounds
- Patent Title (中): 用于改变蛋白质化合物毒性作用的组合物和方法
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Application No.: US10440796Application Date: 2003-05-19
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Publication No.: US07829668B2Publication Date: 2010-11-09
- Inventor: Ellen S. Vitetta , Victor F. Ghetie , Joan Elizabeth Smallshaw , Roxana G. Baluna
- Applicant: Ellen S. Vitetta , Victor F. Ghetie , Joan Elizabeth Smallshaw , Roxana G. Baluna
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Fulbright & Jaworski LLP
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/00
Abstract:
The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
Public/Granted literature
- US20040009148A1 Compositions and methods for modifying toxic effects of proteinaceous compounds Public/Granted day:2004-01-15
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